This ease in the manufacture of methamphetamine has led to the mushrooming of clandestine laboratories for the manufacture of methamphetamine. Estimates in 2006 put the number of such clandestine laboratories manufacturing illegal methamphetamine in the United States of America was more than 6,435, based on the number of laboratory incidents. Most of these laboratories are located in California or in Mexico (OVERVIEW OF METH).According to the National Institute of Drug Abuse (NIDA), in the recent past, there has been an increase in methamphetamine abuse and the problems associated with it in the United States of America. This is reflected in the four-fold increase in the number of people seeking treatment for methamphetamine abuse over the last decade, and the fifty percent increase in emergency calls owing to methamphetamine abuse, over a seven-year period from 1995 to 2002 (Volkow, 2006).Addiction to drugs is a disease of the brain that involves genetic, psychological and social factors. Xu and Zhang (2004), state very clearly that it is the dopaminergic system of the brain that has a central role to play in natural reward and motivation and is the main neural substrate where abusive drugs act on. Such understanding has been arrived at through the analysis of abusive drug action in animals like mice that have been the mainstay of research that aims at providing an understanding of the action of abusive drugs and the cellular and molecular mechanisms involved in compulsive seeking of drugs, drug abuse behavior, relapse into drug use, and the impact of drug abuse on the structures of the brain (Xu amp. Zhang, 2004).An additional facet that has led to a better understanding of drug addiction is the decoding of the human genome. The addiction state is defined on the basis of molecular and cellular adaptations that have occurred at the level of neurons and synapses.
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